Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Amaç: İdiopatik trombositopenik purpura (ITP); trombositopenî, trombosit ömründe kısalma, plazmada anti-trombosit antikorların varlığı ve kemik iliğinde. Immune thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal.

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Most cases respond during the 1 st week of treatment. Our case was abrupt and acute in onset. Petechial spots on dorsum of tongue, petechial spot on left side hard palate and left maxillary tuberosity region.

Transfusion-associated graft versus host disease. Platelet transfusions may be used in severe bleeding together with a very low count. ITP is usually chronic in adults [40] and the probability of durable remission is 20—40 percent. Diseases of the skin and appendages by morphology. British Journal of Haematology. We present a case report on ITP with clinical presentation, diagnosis and management.

Patients are also advised to avoid using aspirin or ibuprofen as pain relievers because these drugs lengthen the clotting time of blood. Secondary causes could be leukemia, medications e. The major goal for treatment of ITP is to provide a safe platelet count to prevent major bleeding and avoid unnecessary treatment of asymptomatic patients with mild to moderate thrombocytopenia.

Hypersensitivity and autoimmune diseases Two distinct clinical syndromes manifest as an acute condition in children and a chronic condition in adults. No significant difference was noted in the rate of survival between males and females. Durable remission following splenectomy is achieved in 75 percent of ITP cases.


Bleeding time from minor lacerations or abrasions is usually prolonged. The evolution of drug discovery: National Heart, Lung, and Blood Institute — www.

Immune thrombocytopenic purpura (ITP)

The following resources can provide more information on ITP: In the United States, the adult chronic population is thought to be approximately 60,—with women outnumbering men approximately 2 to 1, which has resulted in ITP being designated an orphan disease. ITP is an autoimmune disease with antibodies detectable against several platelet surface antigens.

The Netherlands Journal of Medicine. Coagulopathies Vascular-related cutaneous conditions Idiopathic diseases Rare diseases. In approximately 60 percent of cases, antibodies against platelets can be detected. Despite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged.

Please review our privacy policy. ITP affects women more often than men. In mild cases, only careful observation may be required but very low counts or significant bleeding may prompt treatment with corticosteroidsintravenous immunoglobulinanti-D immunoglobulinor immunosuppressive medications.

If the disease does not get better with prednisone, other treatments may include: Patient was also the known case tromnosit ischemic heart disease for past 7 years.

Immune thrombocytopenic purpura – Wikipedia

Cellular immune mechanisms in autoimmune thrombocytopenic purpura: In rare cases, ITP may become a long-term condition in adults and reappear, purpurq after a symptom-free period. Adults are usually started on a steroid medicine called prednisone. The clinical presentation may be acute with severe bleeding, or insidious with slow development with mild or no symptoms.

In recent years, dapsone has also proved helpful in treating lupus, rheumatoid arthritis and as a second-line treatment for ITP. When to Contact a Medical Professional. Foreign Hemolytic disease of the newborn. Bone marrow examination may be performed on patients over the age of 60 and those who do not respond to treatment, or when the diagnosis is in doubt.


Immune thrombocytopenic purpura ITP is a bleeding idioptaik in idilpatik the immune system destroys platelets, which are necessary for normal blood clotting.

Immune thrombocytopenic purpura

The bleeding manifestations of thrombocytopenia are described as mucocutaneous to distinguish them from coagulation disorders like hemophilia. The body destroys the platelets that carry the antibodies. Dapsone also called diphenylsulfone, DDS, or avlosulfon is an anti-infective sulfone drug. Initial laboratory findings useful for predicting the diagnosis of idiopathic thrombocytopenic purpura.

Open in a separate window. ITP is diagnosed by a low platelet count in a complete blood count a common blood test. Platelets help your blood clot by clumping together to plug small holes in damaged blood vessels. This is because the underlying autoimmune mechanism that destroyed the patient’s platelets to begin with will also destroy donor platelets. Fetal blood analysis to determine the platelet count is not generally performed as ITP-induced thrombocytopenia in the fetus is generally less severe than NAIT.

Another option, suitable for Rh-positive patients with functional spleens is intravenous administration of Rho D immune globulin [Human; Anti-D]. Retrieved from ” https: